Publications

Khandelwal NK*, Gupta M*, Gomez JE, Barkho S, Guan Z, Eng AY, Kawate T, Balasubramani SG, Sali A, Hung DT, Stroud RM. Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A. bioRxiv. 2024 Sep bioRxiv 2024.09.04.611325. *equal first authors.

Gupta M*, Khandelwal NK, Nelson A, Hwang P, Pourmal S, Bennett JL*, Stroud RM*. Structural Basis of Aquaporin-4 Autoantibody Binding in Neuromyelitis Optica. bioRxiv. 2024 May 14:2024.05.12.592631. PMID: 38798537. *corresponding authors.

Liu Y, Li C, Gupta M, Stroud RM, Voth GA. Kinetic Network Modeling with Molecular Simulation Inputs: A Proton-Coupled Phosphate Symporter. Biophys J. 2024 Mar 28:S0006-3495(24)00216-9. PMID: 38549372.

Asarnow D, Becker VA, Bobe D, Dubbledam C, Johnston JD, Kopylov M, Lavoie NR, Li Q, Mattingly JM, Mendez JH, Paraan M, Turner J, Upadhye V, Walsh RM Jr, Gupta M*, Eng ET*.  Recent advances in Infectious Disease Research Using Cryo-Electron Tomography. Front Mol Biosci. 2024 Jan 15:10:1296941. PMID: 38288336. *corresponding authors.

Pourmal S, Green E, Bajaj R, Chemmama I, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL, Stroud RM. Structural Basis of Prostaglandin Efflux by MRP4. Nat Struct Mol Biol. 2024 Jan 12; PMID: 38216659.

Bepler T, Borst A, Bouvette J, Cannone G, Chen S, Cheng A, Cheng Ao, Fan Q, Grollios F, Gupta H, Gupta M, Humphreys T, Kim PT, Kuang H, Li Y, Noble A, Punjani A, Rice WJ, Sorzano COS, Stagg S, Strauss J, Yu L, Carragher B, Potter CS. Smart Data Collection for CryoEM. J Struct Biol. 2022; 214 (4) 107913; PMID: 36341954.

Dickinson MS*, Pourmal S*, Gupta M*, Bi M, Stroud RM. Symmetry reduction in a hyperpolarization-activated homotetrameric ion channel. Biochemistry. 2022 Oct 18; 61(20):2177-2181. PMID: 34964607. *equal first authors.

Dickinson MS, Lu J, Gupta M, Marten I, Hedrich R, Stroud RM. Molecular basis of multistep voltage activation in plant two-pore channel 1. Proc Natl Acad Sci USA. 2022; 119 (9) e2110936119. PMID: 35210362.

Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Khalid MM, Taha TY, Tabata T, Hayashi JM, Soveg FW, Carlson-Stevermer J, Gupta M, Zhang MY, Lam V et. al., Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2. Cell Rep. 2022 July 19; Volume 40, Issue 3, 111088; PMID: 35839775.

Maurya PK, Garai P, Goel K, Bhatt H, Dutta A, Goyal A, Dewasthale S, Gupta M, Haokip DT, Barik S, Muthuswami R. Fun30 and Rtt109 Mediate Epigenetic Regulation of the DNA Damage Response Pathway in C. albicans. J Fungi. 2022 May 25;8(6):559. PMID: 35736042.

Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, et. al., CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11. PMID: 34013269.

Liu Y, Li C, Gupta M, Verma N, Johri AK, Stroud RM, Voth GA. Key computational findings reveal proton transfer as driving the functional cycle in the phosphate transporter PiPT. Proc Natl Acad Sci USA. 2021; 25(118):e2101932118. PMID: 34135124.

Li F, Egea PF, Vecchio AJ, Asial I, Gupta M, Paulino J, Bajaj R, Dickinson MS, Ferguson-Miller S, Monk BC, Stroud RM. Highlighting membrane protein structure and function: A celebration of the Protein Data Bank. J Biol Chem. 2021 Mar 17; 100557. PMID: 33744283.

Gordon DE*, Hiatt J*, Bouhaddou M*, Rezelj VV*, Ulferts S*, Braberg H*, Jureka AS*, Obernier K*, Guo JZ*, Batra J*, Kaake RM*, Weckstein AR*, Owens TW*, Gupta M*, Pourmal S*, Titus EW*, et. al., Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521). PMID: 33060197. *equal first authors.

Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, et. al., ...Gupta M, et. al., An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020 Dec 18;370(6523):1473-1479. PMID: 33154106.

Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. Ceapins block the unfolded protein response sensor ATF6a by inducing a neomorphic inter-organelle tether. Elife. 2019 05 31; 8. PMID: 31149896.

Khandelwal NK, Wasi M, Nair R, Gupta M, Kumar M, Mondal AK, Gaur NA, Prasad R. Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast. Antimicrob Agents Chemother. 2019 03; 63(3). PMID: 30642932.

Khandelwal NK, Chauhan N, Sarkar P, Esquivel BD, Coccetti P, Singh A, Coste AT, Gupta M, Sanglard D, White TC, Chauvel M, d'Enfert C, Chattopadhyay A, Gaur NA, Mondal AK, Prasad R. Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling. J Biol Chem. 2018 01 12; 293(2):412-432. PMID: 29158264.

Gupta M, Mazumder M, Dhatchinamoorthy K, Nongkhlaw M, Haokip DT, Gourinath S, Komath SS, Muthuswami R. Ligand-induced conformation changes drive ATP hydrolysis and function in SMARCAL1. FEBS J. 2015 Oct; 282(19):3841-59. PMID: 26195148.

Nongkhlaw M*, Gupta M*, Komath SS, Muthuswami R. Motifs Q and I are required for ATP hydrolysis but not for ATP binding in SWI2/SNF2 proteins. Biochemistry. 2012 May 08; 51(18):3711-22. PMID: 22510062 *equal first authors.